MTRR

Across TCGA patient cohorts, MTRR mutation is significantly associated with the RNA expression of many other genes, with 2,873 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTRR-associated genes across cancer lineages are MRPL37, RTCB, and SRM. Each is linked with MTRR in more than 2 cancer types. Because this analysis shows association rather than direction, both MTRR-to-partner and partner-to-MTRR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL37 grouped by MTRR-low versus MTRR-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTRR→partner) and Y-score (partner→MTRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MRPL37 →	+0.502	+3.360	.004	.005	3	3
UCEC	RTCB →	+0.338	+2.141	.008	.002	3	3
UCEC	SRM →	+0.328	+2.345	.004	<.001	3	3
UCEC	SMYD5 →	+0.225	+1.637	.008	.001	3	3
UCEC	LINC01869 →	+0.254	+1.857	.001	<.001	3	2
UCEC	NME9 →	-0.670	-2.078	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,873 associations by consensus.

MRPL37 by MTRR expression — SKCM

Explore this box plot interactively →