MTRR

Across TCGA patient cohorts, MTRR mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTRR-associated genes across cancer lineages are eEF2, FoxM1, and STAT5a. Each is linked with MTRR in more than 2 cancer types. Because this analysis shows association rather than direction, both MTRR-to-partner and partner-to-MTRR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by MTRR-low versus MTRR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTRR→partner) and Y-score (partner→MTRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.291	+1.765	.008	.013	3	3
UCEC	FoxM1 →	+0.219	+2.857	.006	<.001	3	3
LUSC	STAT5a →	+0.699	+2.816	.017	.036	3	2
UCEC	Caspase-8 →	-0.236	-2.365	.002	<.001	3	2
UCEC	MEK1 →	+0.343	+2.321	.002	<.001	3	2
UCEC	Mre11 →	-0.058	-1.973	.030	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

eEF2 by MTRR expression — UCEC

Explore this box plot interactively →