MTRR

Across TCGA cell cohorts, MTRR RNA expression is significantly associated with the go_rna of many other GO terms, with 3,117 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTRR-associated GO terms across cancer lineages are Protein localization to nuclear inner membrane, L-methionine biosynthetic process, and Protein localization to lipid droplet. Each is linked with MTRR in more than 14 cancer types. Because this analysis shows association rather than direction, both MTRR-to-partner and partner-to-MTRR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to nuclear inner membrane grouped by MTRR-low versus MTRR-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTRR→partner) and Y-score (partner→MTRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Protein localization to nuclear inner membrane →	+0.156	+0.817	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	L-methionine biosynthetic process →	+0.124	+1.195	<.001	<.001	3	15
LUNG_SCLC	Protein localization to lipid droplet →	+0.216	+0.814	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Aspartate family amino acid biosynthetic process →	+0.232	+0.925	<.001	.001	3	13
LARGE_INTESTINE	Transcription by RNA polymerase I →	+0.104	+0.928	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Microtubule organizing center organization →	+0.110	+1.200	<.001	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,117 associations by consensus.

Protein localization to nuclear inner membrane by MTRR expression — BREAST

Explore this box plot interactively →