MTRR

Across TCGA cell cohorts, MTRR mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Myeloma shows the largest number of these associations.

The most reproducible MTRR-associated genes across cancer lineages are SERPINA7, KRT85, and C1orf158. Each is linked with MTRR in more than 1 cancer types. Because this analysis shows association rather than direction, both MTRR-to-partner and partner-to-MTRR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERPINA7 grouped by MTRR-low versus MTRR-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTRR→partner) and Y-score (partner→MTRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1
BLOOD_Myeloma	KRT85 →	+0.026	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1orf158 →	+0.053	+4.807	<.001	.006	3	1
LUNG_NSCLC_LUAD	GUCA1C →	+0.115	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR2L5 →	+0.012	+4.887	.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	HSFY1 →	+0.026	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

SERPINA7 by MTRR expression — BLOOD_Myeloma

Explore this box plot interactively →