MTRNR2L8

Across TCGA pan-cancer cohorts, MTRNR2L8 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated MTRNR2L8 data layer compared with 1 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MTRNR2L8 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MTRNR2L8 expression acts as an unfavorable survival marker, although some lineages such as ACC and READ show a favorable association.

ACC, UCS, and BRCA are the cancer types where MTRNR2L8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.703	0.220	<.001	84	view →
UCS	DFS	Median	II,III,IV	0.147	0.575	.001	72	view →
BRCA	DFS	Quartile	All	0.851	0.940	<.001	61	view →
LUAD	DFS	Tertile	IV	0.459	0.903	.005	39	view →
CHOL	DFS	Tertile	II,III,IV	0.134	0.838	.020	27	view →
READ	OS	Tertile	All	0.853	0.494	.009	21	view →
LGG	OS	Tertile	All	0.873	0.744	.001	18	view →
LIHC	OS	Tertile	II,III,IV	0.609	0.253	.012	15	view →
PCPG	DFS	Median	All	0.635	0.939	.001	12	view →
BLCA	OS	Median	III,IV	0.490	0.177	.019	11	view →
SCLC	OS	Tertile	All	0.826	0.540	.002	10	view →
GBM	OS	Median	All	0.200	0.331	.003	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

MTRNR2L8–ACC (DFS)

Open the ACC breakdown →