MTRNR2L3

Across TCGA pan-cancer cohorts, MTRNR2L3 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MTRNR2L3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MTRNR2L3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MTRNR2L3 is over-expressed in tumor, although a few such as HNSC and BRCA show the opposite, repressed pattern.

KICH, BRCA, and HNSC are the cancer types where MTRNR2L3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MTRNR2L3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	+0.245	.002	5	view →
BRCA	Female	All	+0.126	.016	4	view →
HNSC	All	IV	−0.120	.005	3	view →
BRCA	All	IV	−0.225	.019	2	view →
LIHC	Male	All	−0.086	.003	2	view →
KIRC	Female	All	−0.127	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 5 lineages.

MTRNR2L3–KICH

Open the KICH breakdown →