MTRF1LP1

Across TCGA pan-cancer cohorts, MTRF1LP1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MTRF1LP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MTRF1LP1 RNA is repressed in tumor relative to normal tissue. In most cancer types MTRF1LP1 is over-expressed in tumor, although a few such as HNSC and BRCA show the opposite, repressed pattern.

HNSC, CHOL, and BRCA are the cancer types where MTRF1LP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MTRF1LP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	−0.029	.029	3	view →
CHOL	Female	All	+0.216	.006	2	view →
BRCA	All	III,IV	−0.094	.004	2	view →
KICH	Female	All	+0.077	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

MTRF1LP1–HNSC

Open the HNSC breakdown →