MTRF1L

Across TCGA patient cohorts, MTRF1L mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTRF1L-associated genes across cancer lineages are TIGAR, YB-1, and EGFR_pY1173. Each is linked with MTRF1L in more than 1 cancer types. Because this analysis shows association rather than direction, both MTRF1L-to-partner and partner-to-MTRF1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by MTRF1L-low versus MTRF1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTRF1L→partner) and Y-score (partner→MTRF1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.165	+2.196	.039	.034	3	1
UCEC	YB-1 →	+0.169	+2.196	.042	.034	3	1
UCEC	EGFR_pY1173 →	+0.107	+2.196	.010	.034	2	1
UCEC	Chk2 →	-0.330	-3.321	.007	.010	2	1
UCEC	Notch1 →	+0.189	+3.321	.010	.010	1	1
UCEC	Shc_pY317 →	-0.182	-3.321	.022	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

TIGAR by MTRF1L expression — UCEC

Explore this box plot interactively →