MTRF1L

Across TCGA cell cohorts, MTRF1L RNA expression is significantly associated with the go_rna of many other GO terms, with 4,060 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MTRF1L-associated GO terms across cancer lineages are Termination of RNA polymerase II transcription, Regulation of chromosome separation, and Chromosome segregation. Each is linked with MTRF1L in more than 17 cancer types. Because this analysis shows association rather than direction, both MTRF1L-to-partner and partner-to-MTRF1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Termination of RNA polymerase II transcription grouped by MTRF1L-low versus MTRF1L-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTRF1L→partner) and Y-score (partner→MTRF1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Termination of RNA polymerase II transcription →	+0.121	+0.774	.002	<.001	3	18
KIDNEY	Regulation of chromosome separation →	+0.171	+0.886	<.001	<.001	3	18
KIDNEY	Chromosome segregation →	+0.092	+0.818	<.001	<.001	3	17
KIDNEY	Regulation of mitotic sister chromatid segregation →	+0.154	+0.784	<.001	<.001	3	17
SKIN	Regulation of chromosome segregation →	+0.105	+0.703	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Negative regulation of chromosome segregation →	+0.146	+0.763	<.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,060 associations by consensus.

Termination of RNA polymerase II transcription by MTRF1L expression — SOFT_TISSUE

Explore this box plot interactively →