MTRF1L

Across TCGA cell cohorts, MTRF1L mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTRF1L-associated genes across cancer lineages are MS4A4A, OR52H1, and TAFA1. Each is linked with MTRF1L in more than 1 cancer types. Because this analysis shows association rather than direction, both MTRF1L-to-partner and partner-to-MTRF1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A4A grouped by MTRF1L-low versus MTRF1L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTRF1L→partner) and Y-score (partner→MTRF1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MS4A4A →	+0.186	+3.678	<.001	.009	3	1
LARGE_INTESTINE	OR52H1 →	+0.027	+4.347	<.001	.001	3	1
LARGE_INTESTINE	TAFA1 →	+0.329	+4.688	<.001	<.001	3	1
BLOOD_Leukemia	OR51T1 →	+0.071	+4.922	<.001	.009	3	1
BLOOD_Leukemia	FABP12 →	+0.085	+5.201	<.001	.006	3	1
BLOOD_Leukemia	GSG1L2 →	+0.058	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MS4A4A by MTRF1L expression — LARGE_INTESTINE

Explore this box plot interactively →