MTRF1L

Across TCGA cell cohorts, MTRF1L mutation is significantly associated with the mutation status of many other genes, with 2,599 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTRF1L-associated genes across cancer lineages are E2F3, UGGT1, and LRIG1. Each is linked with MTRF1L in more than 2 cancer types. Because this analysis shows association rather than direction, both MTRF1L-to-partner and partner-to-MTRF1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, E2F3 grouped by MTRF1L-low versus MTRF1L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTRF1L→partner) and Y-score (partner→MTRF1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	E2F3 →	+5.459	+4.744	<.001	<.001	1	3
BLOOD_Leukemia	UGGT1 →	+2.975	+3.794	.006	.006	1	3
BLOOD_Leukemia	LRIG1 →	+4.145	+4.635	.001	.001	1	3
BLOOD_Leukemia	ZHX1 →	+5.560	+4.736	.003	.003	1	3
SKIN	SUCLG2 →	+5.053	+4.239	.007	.007	1	3
BLOOD_Leukemia	SCYL3 →	+5.560	+4.736	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,599 associations by consensus.

E2F3 by MTRF1L expression — LARGE_INTESTINE

Explore this box plot interactively →