MTRF1

Across TCGA patient cohorts, MTRF1 mutation is significantly associated with the RNA expression of many other genes, with 1,932 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTRF1-associated genes across cancer lineages are DCP1A, TAF9, and MYH9. Each is linked with MTRF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTRF1-to-partner and partner-to-MTRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCP1A grouped by MTRF1-low versus MTRF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTRF1→partner) and Y-score (partner→MTRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DCP1A →	+0.582	+2.906	.002	.002	3	2
UCEC	TAF9 →	+0.704	+3.721	<.001	<.001	3	2
UCEC	MYH9 →	+0.581	+3.370	.002	.004	3	2
UCEC	MICU1 →	+0.486	+2.971	<.001	<.001	3	2
UCEC	XPNPEP1 →	+0.499	+2.906	.002	.002	3	2
UCEC	NSD2 →	+0.708	+3.475	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,932 associations by consensus.

DCP1A by MTRF1 expression — UCEC

Explore this box plot interactively →