MTRF1

Across TCGA cell cohorts, MTRF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,561 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MTRF1-associated GO terms across cancer lineages are Mitochondrial translational termination, Translational termination, and Retrograde transport, vesicle recycling within Golgi. Each is linked with MTRF1 in more than 19 cancer types. Because this analysis shows association rather than direction, both MTRF1-to-partner and partner-to-MTRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial translational termination grouped by MTRF1-low versus MTRF1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTRF1→partner) and Y-score (partner→MTRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Mitochondrial translational termination →	+0.143	+1.004	<.001	<.001	3	20
STOMACH	Translational termination →	+0.119	+0.874	<.001	<.001	3	13
LUNG_NSCLC_LUAD	Retrograde transport, vesicle recycling within Golgi →	+0.124	+0.678	<.001	<.001	3	13
LUNG_NSCLC_LUAD	Protein desumoylation →	+0.103	+0.605	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of hematopoietic stem cell differentiation →	+0.116	+0.656	<.001	<.001	3	12
LUNG_NSCLC_LUAD	Post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.099	+0.541	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,561 associations by consensus.

Mitochondrial translational termination by MTRF1 expression — LUNG_SCLC

Explore this box plot interactively →