MTRF1

Across TCGA cell cohorts, MTRF1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MTRF1-associated genes across cancer lineages are NHLH2, OR52K1, and KIR2DS4. Each is linked with MTRF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTRF1-to-partner and partner-to-MTRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NHLH2 grouped by MTRF1-low versus MTRF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTRF1→partner) and Y-score (partner→MTRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NHLH2 →	+0.235	+3.726	<.001	.004	3	1
LARGE_INTESTINE	OR52K1 →	+0.012	+3.632	<.001	.003	3	1
LARGE_INTESTINE	KIR2DS4 →	+0.007	+3.345	<.001	.007	3	1
BLOOD_Leukemia	MRGPRX4 →	+0.012	+4.922	.003	.009	3	1
BLOOD_Leukemia	WFDC11 →	+0.041	+5.539	<.001	.003	3	1
BLOOD_Leukemia	WFDC10B →	+0.063	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

NHLH2 by MTRF1 expression — LARGE_INTESTINE

Explore this box plot interactively →