MTR

Across TCGA patient cohorts, MTR mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTR-associated genes across cancer lineages are Cyclin-E2, JNK_pT183_Y185, and STAT3_pY705. Each is linked with MTR in more than 2 cancer types. Because this analysis shows association rather than direction, both MTR-to-partner and partner-to-MTR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by MTR-low versus MTR-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTR→partner) and Y-score (partner→MTR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Cyclin-E2 →	+0.250	+2.845	.013	.033	3	3
UCEC	JNK_pT183_Y185 →	-0.173	-2.584	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.330	-1.392	<.001	.015	3	2
UCEC	STAT5a →	+0.247	+2.087	.038	.005	3	2
UCEC	ATM →	-0.393	-1.584	.003	.002	3	2
BLCA	ER-alpha_pS118 →	+0.167	+2.820	.012	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Cyclin-E2 by MTR expression — BLCA

Explore this box plot interactively →