MTR

Across TCGA cell cohorts, MTR RNA expression is significantly associated with the go_rna of many other GO terms, with 4,901 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MTR-associated GO terms across cancer lineages are Nuclear export, Regulation of nucleotide-excision repair, and Negative regulation of gene expression, epigenetic. Each is linked with MTR in more than 17 cancer types. Because this analysis shows association rather than direction, both MTR-to-partner and partner-to-MTR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear export grouped by MTR-low versus MTR-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTR→partner) and Y-score (partner→MTR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Nuclear export →	+0.111	+1.214	<.001	<.001	3	18
BONE	Regulation of nucleotide-excision repair →	+0.138	+1.172	<.001	<.001	3	17
STOMACH	Negative regulation of gene expression, epigenetic →	+0.085	+0.693	<.001	.003	3	17
UPPER_AERODIGESTIVE_TRACT	Microtubule polymerization or depolymerization →	+0.103	+1.082	<.001	<.001	3	16
BONE	Subtelomeric heterochromatin formation →	+0.127	+1.110	.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Epigenetic regulation of gene expression →	+0.075	+1.276	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,901 associations by consensus.

Nuclear export by MTR expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →