MTR

Across TCGA cell cohorts, MTR mutation is significantly associated with the RNA expression of many other genes, with 1,223 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTR-associated genes across cancer lineages are C8orf74, PRSS57, and SLC5A1. Each is linked with MTR in more than 1 cancer types. Because this analysis shows association rather than direction, both MTR-to-partner and partner-to-MTR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C8orf74 grouped by MTR-low versus MTR-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTR→partner) and Y-score (partner→MTR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C8orf74 →	+0.020	+2.889	<.001	.002	3	2
LUNG_SCLC	PRSS57 →	+0.266	+4.220	.001	<.001	3	2
LARGE_INTESTINE	SLC5A1 →	+1.342	+2.404	.001	.004	3	2
LARGE_INTESTINE	MCAT →	+0.682	+3.404	<.001	<.001	3	2
LARGE_INTESTINE	C1QBP →	+0.737	+3.036	<.001	<.001	3	2
LARGE_INTESTINE	NDUFC1 →	+0.558	+3.169	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,223 associations by consensus.

C8orf74 by MTR expression — BLOOD_Leukemia

Explore this box plot interactively →