MTPAP

Across TCGA cell cohorts, MTPAP mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTPAP-associated genes across cancer lineages are GUCA1C, TACR3, and CGB8. Each is linked with MTPAP in more than 1 cancer types. Because this analysis shows association rather than direction, both MTPAP-to-partner and partner-to-MTPAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA1C grouped by MTPAP-low versus MTPAP-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTPAP→partner) and Y-score (partner→MTPAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GUCA1C →	+0.024	+4.969	<.001	.003	3	1
BLOOD_Leukemia	TACR3 →	+0.035	+5.060	<.001	.001	3	1
BLOOD_Leukemia	CGB8 →	+0.112	+4.551	<.001	.004	3	1
LUNG_NSCLC_LUAD	OPRPN →	+0.040	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	SPRR4 →	+0.031	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR10J3 →	+0.018	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

GUCA1C by MTPAP expression — BLOOD_Leukemia

Explore this box plot interactively →