Across TCGA patient cohorts, MTOR protein abundance is significantly associated with the RNA expression of many other genes, with 8,964 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible MTOR-associated genes across cancer lineages are MFN2, RPL22L1, and MICOS10. Each is linked with MTOR in more than 4 cancer types. Because this analysis shows association rather than direction, both MTOR-to-partner and partner-to-MTOR results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTOR→partner) and Y-score (partner→MTOR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MFN2 →	+0.670	+0.153	<.001	<.001	3	5
UCEC	RPL22L1 →	-1.088	-0.122	.002	.002	3	5
BRCA	MICOS10 →	+0.479	+0.235	.002	<.001	3	5
LUAD	ELOA →	+0.351	+0.126	<.001	<.001	3	4
OV	LYPLA2 →	+0.447	+0.135	<.001	<.001	3	4
LSCC	ICMT →	+0.507	+0.162	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,964 associations by consensus.

Exploration

MTOR survival (RNA) · tumor vs normal (RNA) · all MTOR data types