Across TCGA patient cohorts, MTOR mutation is significantly associated with the total protein of many other genes, with 78 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTOR-associated genes across cancer lineages are 4E-BP1, GAPDH, and Caspase-7-cleavedD198. Each is linked with MTOR in more than 5 cancer types. Because this analysis shows association rather than direction, both MTOR-to-partner and partner-to-MTOR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTOR→partner) and Y-score (partner→MTOR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	4E-BP1 →	+0.305	+1.813	.002	.016	3	6
KIRC	GAPDH →	+1.301	+3.006	<.001	<.001	3	4
STAD	Caspase-7-cleavedD198 →	+1.160	+2.807	<.001	.002	3	4
LUAD	HER2_pY1248 →	-0.350	-3.153	.008	.018	3	3
KIRC	AMPK_alpha →	+0.356	+3.459	<.001	.005	3	3
KIRC	STAT3_pY705 →	-0.375	-2.315	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

Exploration

MTOR survival (RNA) · tumor vs normal (RNA) · all MTOR data types