Across TCGA cell cohorts, MTOR mutation is significantly associated with the RNA expression of many other genes, with 1,945 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTOR-associated genes across cancer lineages are SIGLEC16, BEND3, and OPCML. Each is linked with MTOR in more than 2 cancer types. Because this analysis shows association rather than direction, both MTOR-to-partner and partner-to-MTOR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTOR→partner) and Y-score (partner→MTOR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SIGLEC16 →	+0.081	+2.469	<.001	.005	3	3
LARGE_INTESTINE	BEND3 →	+0.653	+2.036	<.001	.002	3	3
PANCREAS	OPCML →	+0.006	+5.000	<.001	.006	3	2
BLOOD_Leukemia	C1orf189 →	+0.168	+3.630	<.001	.004	3	2
BLOOD_Leukemia	MAP1LC3C →	+0.036	+2.948	<.001	.008	3	2
BLOOD_Leukemia	MTRNR2L1 →	+0.051	+3.951	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,945 associations by consensus.

Exploration

MTOR survival (RNA) · tumor vs normal (RNA) · all MTOR data types