MTNR1B

Across TCGA patient cohorts, MTNR1B mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTNR1B-associated genes across cancer lineages are eIF4E, Annexin-1, and ATM. Each is linked with MTNR1B in more than 2 cancer types. Because this analysis shows association rather than direction, both MTNR1B-to-partner and partner-to-MTNR1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MTNR1B-low versus MTNR1B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTNR1B→partner) and Y-score (partner→MTNR1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eIF4E →	+0.223	+3.000	.027	.036	3	3
UCEC	Annexin-1 →	+0.631	+3.019	.010	.019	3	2
UCEC	ATM →	-0.534	-3.700	.011	.001	3	2
COAD	Caspase-7-cleavedD198 →	+1.196	+2.815	.005	.036	3	2
UCEC	ERK2 →	+0.239	+3.321	.007	.010	3	1
UCEC	GSK-3_pS9 →	-0.582	-3.321	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

eIF4E by MTNR1B expression — SKCM

Explore this box plot interactively →