MTNR1B

Across TCGA cell cohorts, MTNR1B mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible MTNR1B-associated genes across cancer lineages are TNP1, LRIT2, and ACCSL. Each is linked with MTNR1B in more than 1 cancer types. Because this analysis shows association rather than direction, both MTNR1B-to-partner and partner-to-MTNR1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNP1 grouped by MTNR1B-low versus MTNR1B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTNR1B→partner) and Y-score (partner→MTNR1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TNP1 →	+0.128	+4.415	<.001	.007	3	2
URINARY_TRACT	LRIT2 →	+0.036	+5.087	<.001	.004	3	1
URINARY_TRACT	ACCSL →	+0.013	+5.087	<.001	.004	3	1
STOMACH	SPATA22 →	+0.361	+3.632	.001	.009	3	1
STOMACH	OR5C1 →	+0.026	+3.432	<.001	.008	3	1
STOMACH	ZIC4 →	+0.712	+3.754	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

TNP1 by MTNR1B expression — LARGE_INTESTINE

Explore this box plot interactively →