Across TCGA pan-cancer cohorts, MTND6P12 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MTND6P12’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where MTND6P12 RNA is repressed in tumor relative to normal tissue. In most cancer types MTND6P12 is over-expressed in tumor, although a few such as COAD and STAD show the opposite, repressed pattern.
COAD and STAD are the cancer types where MTND6P12 tumor–normal differential expression is most reproducible.