Across TCGA pan-cancer cohorts, MTND5P35 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MTND5P35’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MTND5P35 RNA is repressed in tumor relative to normal tissue. In most cancer types MTND5P35 is over-expressed in tumor, although a few such as KIRP and LUSC show the opposite, repressed pattern.
KIRP and LUSC are the cancer types where MTND5P35 tumor–normal differential expression is most reproducible.