Across TCGA pan-cancer cohorts, MTND4P3 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MTND4P3’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MTND4P3 RNA is repressed in tumor relative to normal tissue. In most cancer types MTND4P3 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.
KIRC and THCA are the cancer types where MTND4P3 tumor–normal differential expression is most reproducible.