MTND3P25

Across TCGA pan-cancer cohorts, MTND3P25 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of MTND3P25’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MTND3P25 RNA is repressed in tumor relative to normal tissue. In most cancer types MTND3P25 is over-expressed in tumor, although a few such as KIRP and PAAD show the opposite, repressed pattern.

KIRP, BRCA, and KICH are the cancer types where MTND3P25 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MTND3P25 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	All	−0.424	.006	4	view →
BRCA	Female	All	+0.219	.026	4	view →
KICH	All	All	+0.276	.015	3	view →
PAAD	Female	All	−0.605	.040	2	view →
LUSC	All	III,IV	+0.445	.014	2	view →
PRAD	All	All	+0.314	.007	2	view →
COAD	All	II,III,IV	+0.360	.034	1	view →
THCA	Male	All	−0.357	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

MTND3P25–KIRP

Open the KIRP breakdown →