MTND2P40

Across TCGA pan-cancer cohorts, MTND2P40 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MTND2P40’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where MTND2P40 RNA is repressed in tumor relative to normal tissue. In most cancer types MTND2P40 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, HNSC, and BLCA are the cancer types where MTND2P40 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MTND2P40 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.113	<.001	5	view →
HNSC	Male	II,III,IV	+0.068	.014	5	view →
BLCA	Male	All	+0.196	.036	4	view →
COAD	All	II,III,IV	+0.186	.014	4	view →
LIHC	All	All	+0.063	.004	4	view →
CHOL	All	All	+0.497	<.001	3	view →
READ	Female	All	+0.418	<.001	2	view →
KICH	All	II,III,IV	+0.180	.006	2	view →
LUAD	Female	II,III,IV	−0.214	.028	1	view →
STAD	Male	II,III,IV	+0.185	.015	1	view →
BRCA	All	All	+0.136	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MTND2P40–THCA

Open the THCA breakdown →