Across TCGA pan-cancer cohorts, MTND2P23 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MTND2P23’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MTND2P23 RNA is repressed in tumor relative to normal tissue. In most cancer types MTND2P23 is over-expressed in tumor, although a few such as LUSC and KIRC show the opposite, repressed pattern.
LUSC and KIRC are the cancer types where MTND2P23 tumor–normal differential expression is most reproducible.