Across TCGA pan-cancer cohorts, MTND1P36 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MTND1P36’s most consistent transcriptional readouts.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where MTND1P36 RNA is repressed in tumor relative to normal tissue. In most cancer types MTND1P36 is over-expressed in tumor, although a few such as UCEC show the opposite, repressed pattern.
UCEC and BRCA are the cancer types where MTND1P36 tumor–normal differential expression is most reproducible.