MTMR9

Across TCGA patient cohorts, MTMR9 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTMR9-associated genes across cancer lineages are ASNS, ATM, and EGFR_pY1068. Each is linked with MTMR9 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTMR9-to-partner and partner-to-MTMR9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by MTMR9-low versus MTMR9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTMR9→partner) and Y-score (partner→MTMR9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.532	+2.070	<.001	.001	3	2
UCEC	ATM →	-0.464	-2.700	.003	.006	3	2
UCEC	EGFR_pY1068 →	-0.196	-2.000	.024	.030	3	1
UCEC	eIF4E →	+0.156	+2.807	.032	.003	3	1
UCEC	JNK_pT183_Y185 →	-0.119	-1.723	.041	.007	3	1
UCEC	Ku80 →	+0.220	+1.750	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ASNS by MTMR9 expression — UCEC

Explore this box plot interactively →