MTMR6

Across TCGA patient cohorts, MTMR6 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTMR6-associated genes across cancer lineages are GAPDH, MSH2, and MSH6. Each is linked with MTMR6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTMR6-to-partner and partner-to-MTMR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by MTMR6-low versus MTMR6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTMR6→partner) and Y-score (partner→MTMR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.487	+2.321	.003	.005	3	2
UCEC	MSH2 →	-0.314	-4.221	<.001	<.001	3	2
UCEC	MSH6 →	-0.326	-1.755	.001	.013	3	2
UCEC	PCNA →	+0.253	+1.925	<.001	.004	3	2
UCEC	VHL →	-0.868	-2.502	<.001	.001	3	2
UCEC	ATM →	-0.699	-2.115	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

GAPDH by MTMR6 expression — UCEC

Explore this box plot interactively →