MTMR6

Across TCGA cell cohorts, MTMR6 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTMR6-associated genes across cancer lineages are C16orf90, OR2A2, and PTH. Each is linked with MTMR6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTMR6-to-partner and partner-to-MTMR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf90 grouped by MTMR6-low versus MTMR6-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTMR6→partner) and Y-score (partner→MTMR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	C16orf90 →	+0.017	+4.087	<.001	.009	3	1
URINARY_TRACT	OR2A2 →	+0.035	+4.087	<.001	.009	3	1
LUNG_NSCLC_LUAD	PTH →	+0.031	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR8B4 →	+0.034	+4.887	<.001	.009	3	1
LARGE_INTESTINE	GRM4 →	+1.077	+3.491	<.001	.004	3	1
LARGE_INTESTINE	APLNR →	+0.257	+3.799	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

C16orf90 by MTMR6 expression — URINARY_TRACT

Explore this box plot interactively →