MTMR4

Across TCGA patient cohorts, MTMR4 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTMR4-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and GAPDH. Each is linked with MTMR4 in more than 3 cancer types. Because this analysis shows association rather than direction, both MTMR4-to-partner and partner-to-MTMR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by MTMR4-low versus MTMR4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTMR4→partner) and Y-score (partner→MTMR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.271	+3.330	.020	.005	3	3
COAD	Caspase-7-cleavedD198 →	+1.206	+3.000	.001	.035	2	4
COAD	GAPDH →	+0.503	+3.330	.034	.005	3	3
UCEC	14-3-3_beta →	-0.106	-2.973	.001	<.001	3	2
COAD	eEF2 →	+0.378	+2.178	.006	.035	3	2
UCEC	EGFR_pY1068 →	-0.207	-1.459	.011	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

PCNA by MTMR4 expression — COAD

Explore this box plot interactively →