MTMR4

Across TCGA cell cohorts, MTMR4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,001 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MTMR4-associated GO terms across cancer lineages are Negative regulation of endocytic recycling, Subtelomeric heterochromatin formation, and Negative regulation of chromosome condensation. Each is linked with MTMR4 in more than 18 cancer types. Because this analysis shows association rather than direction, both MTMR4-to-partner and partner-to-MTMR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of endocytic recycling grouped by MTMR4-low versus MTMR4-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTMR4→partner) and Y-score (partner→MTMR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Negative regulation of endocytic recycling →	+0.215	+0.770	<.001	.001	3	19
LUNG_SCLC	Subtelomeric heterochromatin formation →	+0.126	+0.848	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome condensation →	+0.167	+1.268	<.001	<.001	3	14
LARGE_INTESTINE	Positive regulation of DNA metabolic process →	+0.069	+1.020	<.001	<.001	3	13
BREAST	Regulation of DNA repair →	+0.057	+1.230	<.001	<.001	3	13
LARGE_INTESTINE	Microtubule nucleation →	+0.130	+1.009	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,001 associations by consensus.

Negative regulation of endocytic recycling by MTMR4 expression — BLOOD_Myeloma

Explore this box plot interactively →