MTMR4

Across TCGA cell cohorts, MTMR4 mutation is significantly associated with the RNA expression of many other genes, with 150 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTMR4-associated genes across cancer lineages are PIWIL3, OR2K2, and PRM3. Each is linked with MTMR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTMR4-to-partner and partner-to-MTMR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIWIL3 grouped by MTMR4-low versus MTMR4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTMR4→partner) and Y-score (partner→MTMR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PIWIL3 →	+0.029	+3.196	<.001	.007	3	2
BLOOD_Leukemia	OR2K2 →	+0.041	+3.818	.003	.007	3	2
BLOOD_Leukemia	PRM3 →	+0.054	+4.984	<.001	.002	3	2
LARGE_INTESTINE	MROH2B →	+0.002	+2.830	<.001	.004	3	2
LUNG_NSCLC_LUSC	KRTAP1-4 →	+0.106	+4.643	<.001	.008	3	1
OESOPHAGUS	OR5P3 →	+0.098	+4.017	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 150 associations by consensus.

PIWIL3 by MTMR4 expression — SKIN

Explore this box plot interactively →