MTMR3

Across TCGA cell cohorts, MTMR3 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MTMR3-associated genes across cancer lineages are GSDMA, C5orf52, and PYDC2. Each is linked with MTMR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTMR3-to-partner and partner-to-MTMR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSDMA grouped by MTMR3-low versus MTMR3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTMR3→partner) and Y-score (partner→MTMR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GSDMA →	+0.139	+3.491	<.001	.008	3	2
SOFT_TISSUE	C5orf52 →	+0.016	+3.977	<.001	.007	3	2
BLOOD_Lymphoma	PYDC2 →	+0.110	+5.247	<.001	.001	3	2
OVARY	OR2L8 →	+0.038	+4.450	<.001	.004	3	2
LUNG_NSCLC_LUSC	CLEC4D →	+0.006	+4.643	<.001	.008	3	1
SOFT_TISSUE	PDHA2 →	+0.016	+3.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

GSDMA by MTMR3 expression — SOFT_TISSUE

Explore this box plot interactively →