MTMR2

Across TCGA patient cohorts, MTMR2 mutation is significantly associated with the RNA expression of many other genes, with 2,685 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTMR2-associated genes across cancer lineages are RNU7-176P, NUDT4P2, and MIR6859-2. Each is linked with MTMR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTMR2-to-partner and partner-to-MTMR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-176P grouped by MTMR2-low versus MTMR2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTMR2→partner) and Y-score (partner→MTMR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU7-176P →	+0.658	+6.618	<.001	.001	3	2
LUSC	NUDT4P2 →	+0.105	+4.392	.001	.006	3	2
UCEC	MIR6859-2 →	+0.308	+1.912	<.001	.005	3	2
COAD	MIR5583-1 →	+0.334	+4.917	.005	.003	3	2
UCEC	RNU1-17P →	+0.180	+2.087	<.001	.009	3	2
UCEC	RNU6-1067P →	+0.204	+1.951	.005	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,685 associations by consensus.

RNU7-176P by MTMR2 expression — BLCA

Explore this box plot interactively →