MTMR2

Across TCGA patient cohorts, MTMR2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTMR2-associated genes across cancer lineages are eEF2, mTOR_pS2448, and PDCD4. Each is linked with MTMR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTMR2-to-partner and partner-to-MTMR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by MTMR2-low versus MTMR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTMR2→partner) and Y-score (partner→MTMR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.406	+2.584	.003	.010	3	2
UCEC	mTOR_pS2448 →	-0.161	-3.565	.004	.002	3	2
UCEC	PDCD4 →	-0.594	-2.105	<.001	.017	3	2
UCEC	Bak →	+0.213	+2.584	.026	.010	3	2
UCEC	c-Kit →	-0.207	-2.087	.020	.005	3	2
UCEC	A-Raf_pS299 →	-0.135	-3.807	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eEF2 by MTMR2 expression — UCEC

Explore this box plot interactively →