MTMR2

Across TCGA cell cohorts, MTMR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,213 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible MTMR2-associated GO terms across cancer lineages are Positive regulation of protein acetylation, Regulation of early endosome to late endosome transport, and Negative regulation of receptor catabolic process. Each is linked with MTMR2 in more than 11 cancer types. Because this analysis shows association rather than direction, both MTMR2-to-partner and partner-to-MTMR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein acetylation grouped by MTMR2-low versus MTMR2-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTMR2→partner) and Y-score (partner→MTMR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Positive regulation of protein acetylation →	+0.102	+0.887	<.001	<.001	3	12
BREAST	Regulation of early endosome to late endosome transport →	+0.169	+1.587	<.001	<.001	3	12
KIDNEY	Negative regulation of receptor catabolic process →	+0.192	+1.232	<.001	<.001	3	12
BREAST	Mitotic metaphase chromosome alignment →	+0.102	+0.982	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Meiotic sister chromatid cohesion, centromeric →	+0.178	+1.132	.001	.001	3	12
PANCREAS	Pyruvate decarboxylation to acetyl-CoA →	+0.178	+1.055	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,213 associations by consensus.

Positive regulation of protein acetylation by MTMR2 expression — LARGE_INTESTINE

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