MTMR14

Across TCGA pan-cancer cohorts, MTMR14 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MTMR14 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MTMR14 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MTMR14 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where MTMR14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.988	0.739	<.001	59	view →
HNSC	OS	Median	II,III,IV	0.952	1.000	.016	18	view →
PDAC	DFS	Median	II,III,IV	0.874	0.678	.001	17	view →
LUAD	OS	Tertile	II,III,IV	0.227	0.764	.026	7	view →
LSCC	DFS	Median	II,III,IV	0.972	0.873	.010	5	view →
UCEC	OS	Median	All	0.860	0.962	.028	4	view →
GBM	DFS	Median	All	0.656	0.776	.039	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MTMR14–CCRCC (DFS)

Open the CCRCC breakdown →