MTMR14

Across TCGA patient cohorts, MTMR14 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTMR14-associated genes across cancer lineages are eIF4E, Notch1, and Annexin-1. Each is linked with MTMR14 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTMR14-to-partner and partner-to-MTMR14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MTMR14-low versus MTMR14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTMR14→partner) and Y-score (partner→MTMR14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.206	+3.013	.025	.018	3	2
UCEC	Notch1 →	+0.190	+1.750	.001	.049	3	2
UCEC	Annexin-1 →	+0.664	+2.807	.003	.003	3	2
UCEC	ATM →	-0.505	-2.115	.010	.019	3	2
SKCM	PKC-delta_pS664 →	-0.204	-2.321	.028	.035	3	2
SKCM	CD49b →	+0.418	+3.169	<.001	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

eIF4E by MTMR14 expression — UCEC

Explore this box plot interactively →