MTMR11

Across TCGA patient cohorts, MTMR11 mutation is significantly associated with the RNA expression of many other genes, with 3,679 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTMR11-associated genes across cancer lineages are MIR557, CCDC163, and SNORD90. Each is linked with MTMR11 in more than 2 cancer types. Because this analysis shows association rather than direction, both MTMR11-to-partner and partner-to-MTMR11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR557 grouped by MTMR11-low versus MTMR11-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTMR11→partner) and Y-score (partner→MTMR11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR557 →	+0.188	+4.389	<.001	.006	3	3
UCEC	CCDC163 →	+0.495	+3.353	<.001	<.001	3	3
SKCM	SNORD90 →	+0.109	+2.436	<.001	.008	3	3
UCEC	GOT1 →	+0.515	+2.600	<.001	<.001	3	3
UCEC	AOC2 →	+1.002	+1.721	<.001	.001	3	3
UCEC	MSANTD3 →	+0.533	+2.233	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,679 associations by consensus.

MIR557 by MTMR11 expression — BRCA

Explore this box plot interactively →