MTMR11

Across TCGA cell cohorts, MTMR11 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTMR11-associated genes across cancer lineages are DEFB108B, TNRC6B, and IL17F. Each is linked with MTMR11 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTMR11-to-partner and partner-to-MTMR11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB108B grouped by MTMR11-low versus MTMR11-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTMR11→partner) and Y-score (partner→MTMR11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DEFB108B →	+0.162	+4.371	<.001	.005	3	1
LARGE_INTESTINE	TNRC6B →	+0.845	+3.064	.001	.009	3	1
LARGE_INTESTINE	IL17F →	+0.042	+2.527	.002	.006	3	1
LARGE_INTESTINE	PDE1A →	+0.227	+3.292	.006	.004	3	1
LARGE_INTESTINE	GALR3 →	+0.082	+3.602	.005	.005	3	1
LARGE_INTESTINE	NCOR1 →	+0.878	+3.064	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

DEFB108B by MTMR11 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →