MTMR10

Across TCGA patient cohorts, MTMR10 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTMR10-associated genes across cancer lineages are Lck, ATM, and 14-3-3_beta. Each is linked with MTMR10 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTMR10-to-partner and partner-to-MTMR10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by MTMR10-low versus MTMR10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTMR10→partner) and Y-score (partner→MTMR10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.133	+1.415	.026	.043	3	2
UCEC	ATM →	-0.540	-2.986	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.083	-1.973	.005	.008	3	1
UCEC	eEF2 →	+0.317	+2.415	.002	.002	3	1
UCEC	EGFR_pY1068 →	-0.317	-2.050	<.001	<.001	3	1
UCEC	eIF4E →	+0.203	+1.584	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Lck by MTMR10 expression — UCEC

Explore this box plot interactively →