MTMR1

Across TCGA pan-cancer cohorts, MTMR1 Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated MTMR1 data layer compared with 27 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MTMR1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MTMR1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

HNSC, KIRC, and BLCA are the cancer types where MTMR1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.087	0.768	<.001	48	view →
KIRC	OS	Median	All	0.062	0.874	<.001	36	view →
BLCA	OS	Median	II,III,IV	1.000	0.408	.016	25	view →
ESCA	DFS	Median	All	0.090	0.536	<.001	18	view →
STAD	OS	Median	II,III,IV	0.153	0.660	.002	15	view →
CESC	DFS	Median	II,III,IV	0.184	0.705	.036	12	view →
LIHC	DFS	Median	All	0.033	0.545	<.001	12	view →
UCEC	OS	Median	All	0.978	0.863	.022	8	view →
LGG	DFS	Median	All	0.185	0.826	<.001	6	view →
SARC	DFS	Median	All	0.101	0.632	.011	6	view →
DLBC	DFS	Median	All	0.416	0.841	.015	5	view →
COAD	OS	Median	All	0.296	0.697	.035	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

MTMR1–HNSC (OS)

Open the HNSC breakdown →