MTM1

Across TCGA patient cohorts, MTM1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTM1-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and eIF4E. Each is linked with MTM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTM1-to-partner and partner-to-MTM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by MTM1-low versus MTM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTM1→partner) and Y-score (partner→MTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.076	-1.558	.005	.015	3	1
UCEC	EGFR_pY1068 →	-0.203	-1.584	.002	.008	3	1
UCEC	eIF4E →	+0.174	+1.959	.002	<.001	3	1
UCEC	ERK2 →	+0.164	+1.643	.001	.002	3	1
UCEC	Heregulin →	-0.082	-1.099	.014	.016	3	1
UCEC	JNK2 →	+0.239	+1.959	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

14-3-3_beta by MTM1 expression — UCEC

Explore this box plot interactively →