MTM1

Across TCGA cell cohorts, MTM1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MTM1-associated genes across cancer lineages are CCL25, FAM71C, and AKAIN1. Each is linked with MTM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTM1-to-partner and partner-to-MTM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL25 grouped by MTM1-low versus MTM1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTM1→partner) and Y-score (partner→MTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CCL25 →	+0.055	+4.095	.004	.009	3	1
SKIN	FAM71C →	+0.017	+4.095	<.001	.009	3	1
SKIN	AKAIN1 →	+0.071	+4.930	<.001	.001	3	1
SKIN	USP17L17 →	+0.010	+5.022	<.001	.002	3	1
BLOOD_Lymphoma	F9 →	+0.035	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	SLC38A8 →	+0.054	+4.191	.009	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

CCL25 by MTM1 expression — SKIN

Explore this box plot interactively →