MTLN

Across TCGA patient cohorts, MTLN RNA expression is significantly associated with the go_rna of many other GO terms, with 7,139 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible MTLN-associated GO terms across cancer lineages are [4Fe-4S] cluster assembly, Establishment of mitotic sister chromatid cohesion, and Ribosome-associated ubiquitin-dependent protein catabolic process. Each is linked with MTLN in more than 26 cancer types. Because this analysis shows association rather than direction, both MTLN-to-partner and partner-to-MTLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, [4Fe-4S] cluster assembly grouped by MTLN-low versus MTLN-high in DLBC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTLN→partner) and Y-score (partner→MTLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	[4Fe-4S] cluster assembly →	+0.065	+0.655	<.001	<.001	3	27
THYM	Establishment of mitotic sister chromatid cohesion →	-0.092	-0.767	<.001	<.001	3	27
THYM	Ribosome-associated ubiquitin-dependent protein catabolic process →	-0.084	-0.768	<.001	<.001	3	26
DLBC	Vesicle cargo loading →	-0.090	-0.656	.004	.004	2	27
THYM	Regulation of termination of DNA-templated transcription →	-0.077	-0.822	<.001	<.001	3	25
THYM	Negative regulation of telomere capping →	-0.065	-0.739	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,139 associations by consensus.

[4Fe-4S] cluster assembly by MTLN expression — DLBC

Explore this box plot interactively →