MTIF2

Across TCGA pan-cancer cohorts, MTIF2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MTIF2 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MTIF2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MTIF2 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

COAD, LUAD, and HNSC are the cancer types where MTIF2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.887	.028	24	view →
LUAD	DFS	Tertile	II,III,IV	0.968	0.688	.006	22	view →
HNSC	OS	Tertile	All	0.924	0.786	.024	8	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.857	.017	7	view →
CCRCC	OS	Median	IV	0.150	0.785	.040	4	view →
GBM	OS	Quartile	All	0.902	0.786	.048	1	view →
PDAC	OS	Quartile	All	0.787	0.894	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MTIF2–COAD (DFS)

Open the COAD breakdown →